Endocrine Abstracts

Hyperandrogenism in women, most typically in polycystic ovary syndrome, is associated with insulin resistance and altered morphology and function of adipose tissue but little is known about the direct effects of androgen on adipose. The aims of this study were to investigate (1) distribution and relative abundance of androgen receptor (AR) in mouse adipose tissue (2) effect of temperature on AR expression in brown and white adipose depots (BAT, WAT) and (3) effects of androgen...

Background and aims: Congenital hypopituitarism (CH) encompasses a spectrum of phenotypes. Known genetic factors account for variable percentage of cases depending on the cohort screened. We analysed the results of genetic screening in a large cohort of patients with CH with the following aims: i) to clarify the genetic aetiology of CH ii) identify any phenotype genotype correlations and iii) propose a screening strategy.Patients and methods: Over 15 yea...